Corticotrophins, corticosteroids, and prostaglandins

Prostaglandins

Knowledge of the structure and synthesis of antibodies (immunoglobulins) has developed to a remarkable degree in the last decade. Distinct classes of immunoglobulin (yG, yM, -yA, yD, yE, and their subgroups) have been identified and shown to consist of fixed numbers of light and heavy polypeptide chains organized in pairs. Each polypeptide has a segment of variable amino acid sequence; the spec...

[Prostaglandins].

Corticosteroids in Infectious Diseases

Accumulated data based on experiences with curtico,teroids in the management uf infectious disea­ses, have proved that they are very dfective and ,afe drugs provided that are administered properly.  The Corticosteroids arc administered mainly be­c,1usc o; antitoxic, antiimflammatory a11d antiallcrgic effects, the cndotoxius are ncuturalized, generalized body reactions are diminished, damaged t...

Cultured lung cells: interplay effects of beta-mimetics, prostaglandins and corticosteroids in the biosynthesis of dipalmitoyl lecithin.

Cell lines derived from type II lung cells were used to study interplays of substances affecting incorporation of labeled precursors [1(-14)C]palmitate and [methyl-3H]choline into phosphatidyl choline. Ethanol stimulated markedly biosynthesis of dipalmitoyl phosphatidyl choline in cloned rabbit lung cells; the stimulating action of ethanol was reduced very much by cortisol and less by ritodrine...

Prostaglandins and glaucoma.

Human aqueous humour was found to contain a substance which contracted the rat stomach strip. The mean activity was significantly higher in specimens from open angle glaucoma cases than in specimens from patients with cataract. The pharmacological and chromatographic properties of the active material were studied in aqueous humour obtained from cadavers; activity seemed to be due to prostagland...